{"id":112828,"date":"2020-04-23T09:17:10","date_gmt":"2020-04-23T07:17:10","guid":{"rendered":"https:\/\/www.erasmusmagazine.nl\/en\/?p=112828"},"modified":"2025-12-19T11:24:54","modified_gmt":"2025-12-19T10:24:54","slug":"why-rotterdam-virologists-dominate-both-talk-shows-and-research","status":"publish","type":"post","link":"https:\/\/www.erasmusmagazine.nl\/en\/2020\/04\/23\/why-rotterdam-virologists-dominate-both-talk-shows-and-research\/","title":{"rendered":"Why Rotterdam virologists dominate both talk shows and research"},"content":{"rendered":"

They regularly make the papers, dominate Dutch talk shows and perform research that stands comparison with the very best worldwide: the virologists at the Erasmus MC are a stand-out bunch. How did the Rotterdam virology institute \u2013 which is relatively young compared to its counterparts throughout the country \u2013 become so good at what it does, and what underlies this success? A historical survey.<\/p>\n

\"\"

The Erasmus MC laboratory <\/span><\/p>

\n\t\n\n<\/svg>\n<\/span>\n\tImage by:<\/span>\n\n\t\t\t\n\t\t\t\t\t\t\tMarko de Haan<\/a>\t\t\t\t\t<\/span>\n\t<\/p>\n<\/figcaption><\/figure>

Marion Koopmans appearing on Radio 1, Marion Koopmans as a guest on TV, Marion Koopmans in NRC Handelsblad<\/em>. And the same story for Ab Osterhaus, former head of the Erasmus MC\u2019s Viroscience department: since the arrival of the pandemic, these researchers have become a fixture of the Dutch media. In these uncertain times, a mass of Dutch viewers and listeners are turning to Rotterdam virologists for explanations.<\/p>\n

Of course, television appearances shouldn\u2019t be taken as a benchmark of quality, but the Rotterdam department is also recognised as an important source of input by the World Health Organisation (WHO) and the Dutch government. And in scientific terms, it ranks as one of the leading institutions worldwide. It has been recognised with a number of awards, including an NWO Stevin Prize in 2018. How did they get there? Four keys to success.<\/p>\n

Nic Masurel: exceptionally talented; exceptionally modest<\/h2>
\"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button>

Nic Masurel, the first head of the Rotterdam virology department.<\/span><\/p>

\n\t\n\n<\/svg>\n<\/span>\n\tImage by:<\/span>\n\n\t\t\t\n\t\t\t\t\t\t\tCollectie Erasmus MC Erfgoed<\/span>\t\t\t\t\t<\/span>\n\t<\/p>\n<\/figcaption><\/figure><\/div>

It all started in 1971. Tucked away in a corner of one of the issues of Nederlands Tijdschrift voor Geneeskunde<\/em> is a notice: \u2018change of address\u2019. In it, one \u2018N. Masurel\u2019 writes: \u201cIn consultation with the State Secretary of Social Affairs and Public Health and the Director-General of the World Health Organisation in Geneva, the WHO\u2019s National Influenza Centre (\u2026) has been moved to Medische Faculteit Rotterdam as of 1 May 1971.\u201d<\/p>\n

\u201cThe establishment of the Virology department in Rotterdam can be traced back to the Leiden-trained virologist Nic Masurel,\u201d says Mart van Lieburg, the Erasmus MC\u2019s resident medical historian. Masurel was a very modest man, and was hardly a born lecturer, but as a researcher, he was one of the best in the world. \u201cHe obtained his doctorate in Leiden in 1957. His research was an absolute world-class publication and established him as one of the best in his field. He demonstrated that different epidemics can be caused by the same pathogen, since viruses are constantly adapting. The pathogen that caused the epidemic of 1956-1957 turned out to be related to that of the Spanish flu.\u201d<\/p>\n

Masurel, who so far had worked as a virologist at the University of Leiden \u2013 a far more prominent institution in the field \u2013 was lured to Medische Faculteit Rotterdam (the precursor of the Erasmus MC) in 1971 by Andries Querido, its founder. Masurel was still planning his move when the decision fell to relocate the WHO\u2019s National Influenza Centre, which until then had also based in Leiden, to the city on the Maas.<\/p>\n\n\t

\n\t\t
\n\t\t\t
\n\t
\n\t\t\u2018Rotterdam had the character and image of a young, can-do team\u2019\n\t<\/blockquote>\n\n\t<\/figure>\n\t\t<\/div>\n\t<\/div>\n

Leiden\u2019s medical faculty had been around for far longer, and they had amassed far more expertise in the field of respiratory infections than their colleagues to the south. But Masurel opted for Rotterdam nevertheless. \u201cRotterdam was a young faculty. And they also had this character and image \u2013 of a young, can-do team of people. There was a unique atmosphere: all sorts of things are possible here. This appealed to him,\u201d says Gerard van Doornum, author of a recent book about Dutch virology.<\/p>\n

It turned out to be a masterstroke on Querido\u2019s masterstroke: Masurel turned his Rotterdam adventure into a success. In twenty years\u2019 time, the veteran researcher set up his own department with seven full-time staff members, put a clear organisational structure in place at a time when such a thing was rarely encountered, drew the WHO\u2019s national agency to Rotterdam and consolidated his research. In 1991, Masurel retired as a professor, and his successor was chosen by an appointment committee, with Masurel in an advising role.<\/p>\n

Rotterdam and animals<\/h2>

Masurel was succeeded by Ab Osterhaus, who originally trained as a veterinarian. And this is by no means an exceptional background for virologists in Rotterdam. Floor Haalboom, who was conferred a doctorate for her research into the treatment of zoonoses in the Netherlands, notes that Rotterdam has a long tradition when it comes to connections between vetinerary science and virology: \u201cThis means that for a very long time, Rotterdam has maintained a very broad perspective on viruses and the possible causes of viral infections.\u201d<\/p>\n

This tradition actually dates back to before the recognition of virology as a separate field, or the establishment of Medische Faculteit Rotterdam \u2013 to the years around 1900. \u201cThe veterinarian-bacteriologist Jan Poels was the director of the national serum institute in Rotterdam. This national institute, which had been founded in 1904, focussed on combating and researching cattle diseases. But thanks to Poels\u2019s wide network, its research also extended to human diseases. In 1911, Poels was appointed endowed professor of Applied Bacteriology in Leiden \u2013 the second veterinarian in the Netherlands to work at a faculty of Medicine.\u201d<\/p>\n\n\t

\n\t\t
\n\t\t\t
\n\t
\n\t\t\u2018This Rotterdam tradition of working closely together with veterinary virologists was continued with Osterhaus\u2019s appointment\u2019\n\t<\/blockquote>\n\n\t<\/figure>\n\t\t<\/div>\n\t<\/div>\n

In the 1930s \u2013 \u2018at that time, the recently-established discipline of virology is seen as very hot\u2019 \u2013 several veterinarians in Leiden worked at the virology department of the local Institute for preventative Medicine. They were also closely associated with research conducted at the national serum institute in Rotterdam. Masurel was taught in Leiden. \u201cIn 1947, Jacob Dirk Verlinde in Leiden was the third veterinarian in the Netherlands to be offered a Virology professorship at a medical faculty. That was by no means a common thing.\u201d<\/p>\n

That Masurel was trained at an institute that also employed a several veterinarians can also be seen in his own research, according to Haalboom. \u201cMasurel obtained a doctorate for a book about the presence of antibodies against swine influenza in human blood. He grew to become a leading proponent of the idea that influenza viruses reach us from the animal world. This Rotterdam tradition of working closely together with veterinary virologists was continued with Osterhaus\u2019s appointment. And it is continued to this day: the current department head, Marion Koopmans, was also trained as a veterinarian.\u201d<\/p>\n

Ab Osterhaus, \u2018extremely dynamic\u2019, enterprising virologist<\/h2>

In contrast with his predecessor, Ab Osterhaus couldn\u2019t be typified as modest, says Van Doornum. This had its advantages: \u201cDuring his term, Osterhaus managed to attract a lot of talented people to Rotterdam. Professors Ron Fouchier, Thijs Kuiken, Marion Koopmans and Guus Rimmelzwaan, for example.\u201d Rob Benner, who served on Osterhaus\u2019s appointment committee at the time: \u201cAb is extremely dynamic. It\u2019s a great experience working with him when you\u2019re a young researcher \u2013 you can learn a lot from him. That drew people in.\u201d<\/p>\n

Benner remembers how around the time of Masurel\u2019s retirement, they were very interested in recruiting Osterhaus for Rotterdam. \u201cWe heard that Osterhaus, who was still working for RIVM at the time, had expressed an interest in Rotterdam \u2013 in part thanks to our ties with the WHO. At the time, he already had a wonderful track record at RIVM and had put together a strong team there \u2013 so we definitely wanted to have him.\u201d<\/p>\n

\"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button>

A young Ab Osterhaus, the gent responsible for attracting a lot of money and talent to Rotterdam.<\/span><\/p>

\n\t\n\n<\/svg>\n<\/span>\n\tImage by:<\/span>\n\n\t\t\t\n\t\t\t\t\t\t\tCollectie Erasmus MC Erfgoed<\/span>\t\t\t\t\t<\/span>\n\t<\/p>\n<\/figcaption><\/figure>

What\u2019s more, he was very inventive when it came to attracting new funding. \u201cWhile Virology was still a relatively small department under Masurel, Osterhaus managed to expand it to some 80 FTEs. In the 1990s \u2013 when various austerity measures had made it difficult to secure a lot of funding \u2013 Ab nevertheless managed to tap into sources in the Netherlands and abroad.\u201d<\/p>\n

Osterhaus also came into some criticism for his entrepreneurial spirit. At the time of the Mexican flu outbreak in 2009, Osterhaus advised the Dutch government to build a large stock of vaccines. Ultimately, there was no need for the bulk of this supply, and Osterhaus turned out to hold shares in the company that was researching the vaccines. Both the hospital and Osterhaus himself have always denied that he derived any financial benefit from this matter. He was allowed to stay on as professor.<\/p>\n

Marion Koopmans: out and about<\/h2>

In 2013 Ab Osterhaus became emeritus professor, and Marion Koopmans became the head of Viroscience Leiden. \u201cShe also worked for RIVM for many years, where she mainly focused on epidemiology. That\u2019s also why she was appointed to the Outbreak Management Team (OMT),\u201d says Van Doornum. In addition, Koopmans plays an important role as key adviser to the WHO.<\/p>\n

\"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button>

Marion Koopmans, celebrated for her ability to create global networks for the systematic and large-scale control of infectious diseases. <\/span><\/p>

\n\t\n\n<\/svg>\n<\/span>\n\tImage by:<\/span>\n\n\t\t\t\n\t\t\t\t\t\t\tRafa\u00ebl Philippen<\/span>\t\t\t\t\t<\/span>\n\t<\/p>\n<\/figcaption><\/figure><\/div>

Koopmans is celebrated for her ability to create \u201cglobal networks for the systematic and large-scale control of infectious diseases,\u201d wrote the Dutch Research Council (NWO) in its jury report for the 2018 Stevin Prize, the Netherland\u2019s most prestigious award for knowledge utilisation for the benefit of society. During the ebolavirus crisis of 2015, Koopmans travelled to Africa to set up three mobile laboratories, and she could also be found in South America and the Caribbean at the time of the zikavirus outbreak. In addition, she set up an online database that enables the early detection of infectious diseases worldwide.<\/p>\n

That\u2019s also characteristic for the \u2018Rotterdam school of virology\u2019, says Benner. \u201cThey go out into the world to collect and identify virus samples in the field, across the planet. And they tend to be highly successful in this undertaking because they form a diverse group of scientists, who specialise in different parts of the virology field.\u201d Van Doornum: \u201cDuring the SARS outbreak of 2003, Rotterdam was the only Dutch virology department to participate in research performed on location. And by the time MERS presented itself [like SARS, another coronavirus, Eds.], Rotterdam had already amassed experience in this area.\u201d<\/p>\n

But, says Van Doornum, we shouldn\u2019t turn this into a contest or keep blowing our own horn. \u201cIt\u2019s not about Rotterdam outshining Amsterdam, or leading the international field. Collaboration is far more important for the end result than racking up the most citations or drawing in the star players.\u201d<\/p>\n

\"\"\n\t\t\t\n\t\t\t\t\n\t\t\t<\/svg>\n\t\t<\/button>

Microtome from around 1965. This machine made it possible to cut thin slices or slices very accurately, a condition to study specimens under a microscope. The microtome consists of a very sharp knife that is stable and can be moved along the cutting block. This specimen has played a crucial role in research which has contributed to the status 'Regional Expertise Centre'.<\/span><\/p>

\n\t\n\n<\/svg>\n<\/span>\n\tImage by:<\/span>\n\n\t\t\t\n\t\t\t\t\t\t\tCollectie Erasmus MC erfgoed<\/span>\t\t\t\t\t<\/span>\n\t<\/p>\n<\/figcaption><\/figure>\n\t

\n\t\t\t\t\t

De redactie<\/h2>\n\t\t\n\t\t
\n\n\t\t\t\n\t\t\t